Lymphoma at King Hussein Medical Center: a histopathologic review

To determine the spectrum of various types of malignant lymphoma in children and adults at King Hussein Medical Center according to the World Health Organization classification 2001. A retrospective review of the histopathological subtypes of all primary lymphoma cases was conducted at Princess Iman Research and Laboratory Sciences Center at King Hussein Medical Center during the period between January 2004 and December 2008. A total of 485 patients were studied regarding: age, gender, and Lymphoma type using the World Health Organization classification of lymphoid neoplasms. Descriptive analysis using frequencies was used to describe the study variables. Two hundred seventy-four [56.5%] cases were males and 211 [43.5%] were females. Their ages ranged between two and ninety years. A total of 61 [12.6%] patients were children and 424 [87.4%] patients were > 14 years old. Of 485 patients included in the study, 342 patients [70.5%] had non-Hodgkin's lymphoma and 143[29.5%] had Hodgkin's lymphoma. Two hundred twenty nine [47.2%] of affected patients aged 50 years and above, non-Hodgkin's Lymphoma accounted for 206 patients [90%] of them. Of all pediatric lymphoma cases, Hodgkin's lymphoma accounted for 41% [25 cases] and Non-Hodgkin's Lymphoma 59% [36 cases]. Burkitt's lymphoma was the predominant lymphoma in children. In the adult NHL group, diffuse large B-cell lymphoma was the most common followed by follicular lymphoma. In the HL group, the nodular sclerosis variant was the most frequent [63.6%, 91 patient] followed by the mixed cellularity type [20.3%, 29 patient]. Distribution and patterns of lymphoma differs between children and adults. Diffuse large B-cell lymphoma is the most commonly encountered lymphoma in adults. Burkitt's lymphoma and Hodgkin's lymphoma are the predominant childhood lymphomas.

Clinicopathdlogicai of Clinicopathological study of extranodal Non-Hodgkin Lymphoma [NHLS] at Armed Forces Institute of Pathology [AFIP] Pakistan

To evaluate the Clinicopathological analysis of extranodal Non-Hodgkin Lymphoma [NHLs] reported in Armed Forces institute of Pathology [AFIP] Rawalpindi, Pakistan. Record of a total of 206 cases of extranodal NHLs diagnosed between January 2009 to December 2010 was retrieved from AFIP tumour registry. Basic epidemiological data regarding each case was collected from the request forms. The specimens were received in 10% formal saline. Gross examination of surgical specimens was performed arid recorded on a proforma. The material was processed under standardized conditions for paraffin embedding. The sections were stained with hematoxylin and eosin [H/E]. Immunohistochemistry panel was applied for the categorization of the lymphomas according to the 2008 WHO guidelines. Data was entered and analysed on SPSS version 14. Out of 206 cases, 147 [71.3%] were males and 59 were females [28.6%]. Male to female ratio was 2.4:1. The age ranged between 7-99 years. The most commonly affected age group was the 5[th] decade with 40 cases [19,4%], The most commonly involved site was head and neck, 85 cases [41.2%], followed by the GIT, 61 cases [29.6%]. Diffuse large B-cell lymphoma [DLBCL], was the most common histologic type, 165 cases [80%].Diffuse large B-cell lymphoma is the most common extranodal Non Hodgkin lymphoma, in our population

Small B cell Non-Hodgkins Lymphoma in Pakistan

To study the pattern of small B cell lymphomas in Pakistan. This descriptive study was carried out at the Aga Khan University Hospital pathology department including 1721 cases of Non-Hodgkins Lymphoma [NHL] diagnosed during a period of five years [1998-2002] and classified according to REAL/WHO classification. The antibodies used included Leukocyte Common Antigen [LCA], Pan B [CD20, CD79a], Pan T [UCHL-1], Bcl 2, Mib 1[Ki 67] and Cyclin D1 [Dako, Denmark]. Out of the 1721 NHL cases, only 140 [8.1%] could be categorized as small B-cell NHL. The study group comprised small lymphocytic lymphoma/chronic lymphocytic leukemia [58 cases; 41.4%] followed by follicular lymphoma [46 cases; 32.9%], mantle cell lymphoma [15 cases; 10.7%], extra nodal marginal zone B cell lymphoma of MALT type [15 cases; 10.7%], lymphoplasmacytic lymphoma [5 cases; 3.6%] and splenic marginal zone B-cell lymphoma [1 case; 0.7%]. No case of nodal marginal zone lymphoma was diagnosed. The age ranged from 18 to 98 years with a mean and median of 54.64 and 58.50 years respectively. Small B-cell NHL was more common in males; with male to female ratio of 2.1. Majority of the small B-cell NHL were nodal at presentation with a nodal to extranodal ratio of 3.4. It is concluded that the frequency of these small B-cell NHL is very low in our population in contrast to the western literature. Further studies based on epidemiologic and etiological factors are required to look into this marked difference of occurrence of these indolent lymphomas

Diffuse large B cell lymphoma (DLBCL) in Pakistan: an emerging epidemic?

There has been a recent concern among oncological clinicians and pathologists of our region regarding the disproportionate increase in the number of patients presenting with diffuse large B cell lymphoma (DLBCL). This prompted us to conduct a thorough, hospital-based epidemiological study in a major referral center of Pakistan. A total of 780 specimens were collected over last half decade from cases classified as adult Non Hodgkin's lymphoma (NHL). Out of these 780, 596 (76.4 %) were diagnosed as DLBCLs. The gender ratio was 2.3:1 (M:F) and the median age was 47.2 years, with an age range of 15-85 years. Nodal-NHLs constituted 42.2 % of all adult NHLs, with the cervical lymph nodes as the most frequent nodal site of presentation. The most frequent extranodal site was the gastro-intestinal tract (GIT), followed by the head and neck. In conclusion, we document an astonishingly high number of DLBCL amounting to an emerging epidemic in Pakistan, with a consideration of probable etiopathogenetic factors.

Helicobacter pylori: su importancia como problema de salud en la comunidad / Helicobacter pylori: its importance as a health problem in the community

El presente trabajo es una revisión de los anexos existentes entre el Helicobacter pylori y la gastritis crónica, la úlcera gastroduodenal, el cáncer gástrico, el linfoma de células B y algunos aspectos relacionados con la epidemiología y el tratamiento de esta infección. Se sugiere la posibilidad de que modelos de infección semejantes se asocien a otras enfermedades así como el hecho de que ésta, procedente de Europa, se haya introducido en América como consecuencia del encuentro de estas 2 culturas